Sequencing primer compatibility of Illumina libraries and recommended library types for the iSeq 100 sequencing platform

04/07/22


Illumina offers a wide array of library preparation kits and sequencing platforms for different applications, each with its own coverage and indexing considerations. The table below lists the Illumina sequencing primers and library preparation kits compatible with the iSeq 100 platform based on the required data output*, read length, and the indexing capabilities of each kit.

Note: Most Illumina libraries can be sequenced with all Illumina sequencing platforms. If a specific Illumina library is not listed below, contact Illumina Tech Support to discuss special considerations.

Refer to the Sequence Coverage Calculator and Library Prep and Array Kit Selector resources for additional information.

Table 1. Compatible sequencing primers and recommended library types for the iSeq 100 sequencing platform.

iSeq100
Read 1
Primer
Index 1 (i7)
Primer
Index 2 (i5)
Primer
Read 2
Primer
Library Type
HP10 HP14 HP14 HP11 AmpliSeq Panels
Illumina DNA Prep (M) Tagmentation
Illumina DNA Prep with Enrichment
(with small panels)
Nextera Rapid Capture Custom Enrichment
Nextera XT DNA
TruSeq ChIP
TruSeq DNA PCR-Free
TruSeq Nano DNA
TruSeq RNA v2
TruSeq Small RNA
TruSeq Targeted RNA Expression
Panels
TruSight Cancer
TruSight Cardio
TruSight Inherited Disease
TruSight Myeloid
TruSight Rapid Capture
TruSight RNA Fusion
TruSight RNA Pan-Cancer
TruSight Tumor 15

 

*The iSeq 100 sequencing platform has a maximum data output of 1.2 Gb.